| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GLYA | PEPB | PBPRA0795 | PBPRA0758 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | 0.814 |
| GLYA | SF0285 | PBPRA0795 | PBPRA0833 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative aminoacyl-histidine dipeptidase; Predicted by orpheus program; predicted by glimmer program. | 0.897 |
| GLYA | SF2570 | PBPRA0795 | PBPRA0757 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative peptidase B (Aminopeptidase B); Probably plays an important role in intracellular peptide degradation. | 0.814 |
| GLYA | SF4229 | PBPRA0795 | PBPRA0484 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative aminopeptidase A/I; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.814 |
| GLYA | STM1057 | PBPRA0795 | PBPRA1764 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative aminopeptidase N; Predicted by orpheus program; predicted by glimmer program. | 0.853 |
| GLYA | VVA0031 | PBPRA0795 | PBPRB1479 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative Glutathione synthase; Predicted by orpheus program; predicted by glimmer program; Belongs to the prokaryotic GSH synthase family. | 0.804 |
| GLYA | VVA0693 | PBPRA0795 | PBPRB1322 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.903 |
| GLYA | gshB | PBPRA0795 | PBPRA3138 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative glutathione synthetase; Predicted by orpheus program; predicted by glimmer program; Belongs to the prokaryotic GSH synthase family. | 0.811 |
| PEPB | GLYA | PBPRA0758 | PBPRA0795 | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.814 |
| PEPB | RSC2921 | PBPRA0758 | PBPRA3512 | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | Putative gamma-glutamyltranspeptidase; Predicted by orpheus program; predicted by glimmer program. | 0.924 |
| PEPB | S2902 | PBPRA0758 | PBPRA3047 | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | Putative glutamate-cysteine ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. | 0.908 |
| PEPB | SF0285 | PBPRA0758 | PBPRA0833 | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | Putative aminoacyl-histidine dipeptidase; Predicted by orpheus program; predicted by glimmer program. | 0.914 |
| PEPB | SF2570 | PBPRA0758 | PBPRA0757 | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | Putative peptidase B (Aminopeptidase B); Probably plays an important role in intracellular peptide degradation. | 0.951 |
| PEPB | SF4229 | PBPRA0758 | PBPRA0484 | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | Putative aminopeptidase A/I; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.924 |
| PEPB | STM1057 | PBPRA0758 | PBPRA1764 | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | Putative aminopeptidase N; Predicted by orpheus program; predicted by glimmer program. | 0.940 |
| PEPB | VVA0031 | PBPRA0758 | PBPRB1479 | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | Putative Glutathione synthase; Predicted by orpheus program; predicted by glimmer program; Belongs to the prokaryotic GSH synthase family. | 0.921 |
| PEPB | VVA0693 | PBPRA0758 | PBPRB1322 | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | Putative glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.814 |
| PEPB | gshB | PBPRA0758 | PBPRA3138 | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | Putative glutathione synthetase; Predicted by orpheus program; predicted by glimmer program; Belongs to the prokaryotic GSH synthase family. | 0.921 |
| RSC2921 | PEPB | PBPRA3512 | PBPRA0758 | Putative gamma-glutamyltranspeptidase; Predicted by orpheus program; predicted by glimmer program. | Putative peptidase B; Probably plays an important role in intracellular peptide degradation. | 0.924 |
| RSC2921 | S2902 | PBPRA3512 | PBPRA3047 | Putative gamma-glutamyltranspeptidase; Predicted by orpheus program; predicted by glimmer program. | Putative glutamate-cysteine ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. | 0.922 |