| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C0250 | SO1638 | PBPRA2919 | PBPRA2959 | Hypothetical SAM-dependent methyltransferase; Predicted by orpheus program; predicted by glimmer program. | Putative outer membrane protein OmpH; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | 0.642 |
| C0250 | VV3014 | PBPRA2919 | PBPRA0255 | Hypothetical SAM-dependent methyltransferase; Predicted by orpheus program; predicted by glimmer program. | Hypothetical cell division protein; Predicted by orpheus program; predicted by glimmer program. | 0.422 |
| C0250 | YPO2877 | PBPRA2919 | PBPRA0765 | Hypothetical SAM-dependent methyltransferase; Predicted by orpheus program; predicted by glimmer program. | Conserved hypothetical protein; Predicted by orpheus program; predicted by glimmer program. | 0.586 |
| C0250 | YPO3572 | PBPRA2919 | PBPRA3245 | Hypothetical SAM-dependent methyltransferase; Predicted by orpheus program; predicted by glimmer program. | Conserved hypothetical protein; Predicted by orpheus program; predicted by glimmer program. | 0.548 |
| C0250 | smg | PBPRA2919 | PBPRA3576 | Hypothetical SAM-dependent methyltransferase; Predicted by orpheus program; predicted by glimmer program. | Putative Smg protein; Predicted by orpheus program; predicted by glimmer program; Belongs to the Smg family. | 0.494 |
| C0250 | zapD | PBPRA2919 | PBPRA3205 | Hypothetical SAM-dependent methyltransferase; Predicted by orpheus program; predicted by glimmer program. | Conserved hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. | 0.724 |
| FTSZ | VV3014 | PBPRA3211 | PBPRA0255 | Putative cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Hypothetical cell division protein; Predicted by orpheus program; predicted by glimmer program. | 0.501 |
| FTSZ | zapD | PBPRA3211 | PBPRA3205 | Putative cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Conserved hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. | 0.894 |
| PSPTO092 | SF0100 | PBPRA3203 | PBPRA3204 | Putative leader peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. | Hypothetical dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.917 |
| PSPTO092 | VV2784 | PBPRA3203 | PBPRA3206 | Putative leader peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. | Conserved hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.731 |
| PSPTO092 | zapD | PBPRA3203 | PBPRA3205 | Putative leader peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. | Conserved hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. | 0.785 |
| SF0100 | PSPTO092 | PBPRA3204 | PBPRA3203 | Hypothetical dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Putative leader peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. | 0.917 |
| SF0100 | VV2784 | PBPRA3204 | PBPRA3206 | Hypothetical dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Conserved hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.738 |
| SF0100 | zapD | PBPRA3204 | PBPRA3205 | Hypothetical dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Conserved hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. | 0.982 |
| SO1638 | C0250 | PBPRA2959 | PBPRA2919 | Putative outer membrane protein OmpH; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | Hypothetical SAM-dependent methyltransferase; Predicted by orpheus program; predicted by glimmer program. | 0.642 |
| SO1638 | VV3014 | PBPRA2959 | PBPRA0255 | Putative outer membrane protein OmpH; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | Hypothetical cell division protein; Predicted by orpheus program; predicted by glimmer program. | 0.501 |
| SO1638 | YPO2877 | PBPRA2959 | PBPRA0765 | Putative outer membrane protein OmpH; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | Conserved hypothetical protein; Predicted by orpheus program; predicted by glimmer program. | 0.482 |
| SO1638 | YPO3572 | PBPRA2959 | PBPRA3245 | Putative outer membrane protein OmpH; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | Conserved hypothetical protein; Predicted by orpheus program; predicted by glimmer program. | 0.580 |
| SO1638 | zapD | PBPRA2959 | PBPRA3205 | Putative outer membrane protein OmpH; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. | Conserved hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. | 0.731 |
| VV2784 | PSPTO092 | PBPRA3206 | PBPRA3203 | Conserved hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | Putative leader peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. | 0.731 |