Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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METHPutative cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1223 aa)    
Predicted Functional Partners:
T3511
Putative 5,10-methylenetetrahydrofolate reductase; Predicted by orpheus program; predicted by glimmer program; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.997
METE
Putative 5-Methyltetrahydropteroyltriglutamate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.995
Z5494
Putative cystathionine gamma-synthase; Predicted by orpheus program; predicted by glimmer program.
  
 
 0.978
S3256
Putative cystathionine beta-lyase; Predicted by orpheus program; predicted by glimmer program.
  
 
 0.978
STM4101
Putative aspartokinase II/homoserine dehydrogenase, methionine-sensitive; Predicted by orpheus program; predicted by glimmer program; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.975
Y3718
Putative aspartokinase I/homoserine dehydrogenase; Predicted by orpheus program; predicted by glimmer program; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.975
CV1934
Putative homocysteine synthase; Predicted by orpheus program; predicted by glimmer program.
  
 
 0.971
S2901
Putative autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
    
 0.969
metK
Putative MetK, S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.962
FHS
Putative formate-tetrahydrofolate ligase; Predicted by orpheus program; predicted by glimmer program; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.961
Your Current Organism:
Photobacterium profundum
NCBI taxonomy Id: 298386
Other names: P. profundum SS9, Photobacterium SS9, Photobacterium profundum SS9, Photobacterium profundum str. SS9, Photobacterium profundum strain SS9, Photobacterium sp. (strain SS9), Photobacterium sp. SS9, deep-sea eubacterium SS9
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