Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
Z5317Hypothetical uroporphyrin-III C-methyltransferase; Predicted by orpheus program; predicted by glimmer program. (433 aa)    
Predicted Functional Partners:
T3360
Hypothetical uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.995
PLU4647
Hypothetical HemY protein; Predicted by orpheus program; predicted by glimmer program.
 
  
 0.989
STY4319
Putative siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
     
 0.908
S3666
Putative uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.907
T4028
Putative Uroporphyrinogen-III methylase; Predicted by orpheus program; predicted by glimmer program; Belongs to the precorrin methyltransferase family.
     
  0.900
PP3999
Putative uroporphyrin-III C-methyltransferase; Predicted by orpheus program; predicted by glimmer program.
     
  0.900
COBA2
Hypothetical siroheme synthase component enzyme; Predicted by orpheus program; predicted by glimmer program.
     
 0.900
HEMC
Putative porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
  
 0.881
S3879
Hypothetical protein; Predicted by orpheus program; predicted by glimmer program.
  
  
 0.881
CYAA
Putative adenylate cyclase; Predicted by orpheus program; predicted by glimmer program; Belongs to the adenylyl cyclase class-1 family.
 
    0.782
Your Current Organism:
Photobacterium profundum
NCBI taxonomy Id: 298386
Other names: P. profundum SS9, Photobacterium SS9, Photobacterium profundum SS9, Photobacterium profundum str. SS9, Photobacterium profundum strain SS9, Photobacterium sp. (strain SS9), Photobacterium sp. SS9, deep-sea eubacterium SS9
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