| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HEMB | S3666 | PBPRA0123 | PBPRA3428 | Putative delta-aminolevulinic acid dehydratase; Predicted by orpheus program; predicted by glimmer program; Belongs to the ALAD family. | Putative uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.885 |
| HEMB | SF2489 | PBPRA0123 | PBPRA3572 | Putative delta-aminolevulinic acid dehydratase; Predicted by orpheus program; predicted by glimmer program; Belongs to the ALAD family. | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.669 |
| HEMB | Z5403 | PBPRA0123 | PBPRA3497 | Putative delta-aminolevulinic acid dehydratase; Predicted by orpheus program; predicted by glimmer program; Belongs to the ALAD family. | Putative oxygen-independent coproporphyrinogen III oxidase; Predicted by orpheus program; predicted by glimmer program; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.490 |
| HEMB | hemH | PBPRA0123 | PBPRA1025 | Putative delta-aminolevulinic acid dehydratase; Predicted by orpheus program; predicted by glimmer program; Belongs to the ALAD family. | Putative ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.659 |
| PMT0855 | SF2489 | PBPRB0769 | PBPRA3572 | Hypothetical isochorismatase family protein; Predicted by orpheus program; predicted by glimmer program. | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.709 |
| PURK | SF2489 | PBPRA3574 | PBPRA3572 | Hypothetical phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.680 |
| PURK | SO0040 | PBPRA3574 | PBPRA3571 | Hypothetical phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | Putative shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.624 |
| PURK | STY4397 | PBPRA3574 | PBPRA3570 | Hypothetical phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | Conserved hypothetical protein; Predicted by orpheus program; predicted by glimmer program. | 0.598 |
| PURK | YRDC | PBPRA3574 | PBPRA3573 | Hypothetical phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | Putative Sua5/YciO/YrdC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. | 0.718 |
| S3666 | HEMB | PBPRA3428 | PBPRA0123 | Putative uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Putative delta-aminolevulinic acid dehydratase; Predicted by orpheus program; predicted by glimmer program; Belongs to the ALAD family. | 0.885 |
| S3666 | SF2489 | PBPRA3428 | PBPRA3572 | Putative uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.973 |
| S3666 | Z5403 | PBPRA3428 | PBPRA3497 | Putative uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Putative oxygen-independent coproporphyrinogen III oxidase; Predicted by orpheus program; predicted by glimmer program; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.961 |
| S3666 | hemH | PBPRA3428 | PBPRA1025 | Putative uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | Putative ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.937 |
| SF2489 | HEMB | PBPRA3572 | PBPRA0123 | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Putative delta-aminolevulinic acid dehydratase; Predicted by orpheus program; predicted by glimmer program; Belongs to the ALAD family. | 0.669 |
| SF2489 | PMT0855 | PBPRA3572 | PBPRB0769 | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Hypothetical isochorismatase family protein; Predicted by orpheus program; predicted by glimmer program. | 0.709 |
| SF2489 | PURK | PBPRA3572 | PBPRA3574 | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Hypothetical phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.680 |
| SF2489 | S3666 | PBPRA3572 | PBPRA3428 | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Putative uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.973 |
| SF2489 | SO0040 | PBPRA3572 | PBPRA3571 | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Putative shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.785 |
| SF2489 | STY3573 | PBPRA3572 | PBPRA0067 | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Putative protoporphyrinogen oxidase; Predicted by orpheus program; predicted by glimmer program. | 0.941 |
| SF2489 | STY4397 | PBPRA3572 | PBPRA3570 | Putative coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Conserved hypothetical protein; Predicted by orpheus program; predicted by glimmer program. | 0.731 |