STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
COBUPutative cobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (192 aa)    
Predicted Functional Partners:
VV0634
Hypothetical cobalamin biosynthesis protein CbiB; Predicted by orpheus program; predicted by glimmer program.
 
 
 0.991
VV1474
Hypothetical nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
  
 0.987
VV1475
Cobalamin 5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
 
 0.986
RS02759
Putative cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.986
SO1039
Putative cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
 
  
 0.982
XAC3185
Hypothetical protein; Predicted by orpheus program; predicted by glimmer program.
 
  
 0.949
STY4319
Putative siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
 
  
 0.519
ECS1085
Hypothetical protein; Predicted by orpheus program; predicted by glimmer program.
       0.465
PP3999
Putative uroporphyrin-III C-methyltransferase; Predicted by orpheus program; predicted by glimmer program.
 
  
 0.443
T4028
Putative Uroporphyrinogen-III methylase; Predicted by orpheus program; predicted by glimmer program; Belongs to the precorrin methyltransferase family.
 
  
 0.439
Your Current Organism:
Photobacterium profundum
NCBI taxonomy Id: 298386
Other names: P. profundum SS9, Photobacterium SS9, Photobacterium profundum SS9, Photobacterium profundum str. SS9, Photobacterium profundum strain SS9, Photobacterium sp. (strain SS9), Photobacterium sp. SS9, deep-sea eubacterium SS9
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.