STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
HISCPutative histidinol phosphate aminotransferase; Predicted by orpheus program; predicted by glimmer program. (362 aa)    
Predicted Functional Partners:
hisB
Putative imidazoleglycerol-phosphatedehydratase/histidinol- phosphatase; Predicted by orpheus program; predicted by glimmer program; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
 
 0.999
VV1351
Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.996
VV12913
Putative phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; Predicted by orpheus program; predicted by glimmer program; In the C-terminal section; belongs to the PRA-PH family.
 
  
 0.993
STM2669
Putative chorismate mutase/prephenate dehydrogenase; Predicted by orpheus program; predicted by glimmer program.
 
 
 0.992
HISG
Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.982
SF2085
Putative glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.981
S2208
Putative imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.975
hisA
Putative phosphoribosylformimino-5-aminoimidazole carboxamideribonucleotide isomerase; Predicted by orpheus program; predicted by glimmer program.
 
  
 0.973
PM0150
Putative chorismate mutase/prephenate dehydratase; Predicted by orpheus program; predicted by glimmer program.
 
 
 0.960
PP4490
Putative phenylalanine-4-hydroxylase; Predicted by orpheus program; predicted by glimmer program.
     
 0.929
Your Current Organism:
Photobacterium profundum
NCBI taxonomy Id: 298386
Other names: P. profundum SS9, Photobacterium SS9, Photobacterium profundum SS9, Photobacterium profundum str. SS9, Photobacterium profundum strain SS9, Photobacterium sp. (strain SS9), Photobacterium sp. SS9, deep-sea eubacterium SS9
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