STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CV1934Putative homocysteine synthase; Predicted by orpheus program; predicted by glimmer program. (422 aa)    
Predicted Functional Partners:
C4970
Putative homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.
 
 
 0.975
METH
Putative cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.971
S3256
Putative cystathionine beta-lyase; Predicted by orpheus program; predicted by glimmer program.
 
 
0.947
Z5494
Putative cystathionine gamma-synthase; Predicted by orpheus program; predicted by glimmer program.
 
 
0.941
METE
Putative 5-Methyltetrahydropteroyltriglutamate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.940
BH3313
Putative PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; Predicted by orpheus program; predicted by glimmer program.
   
 0.935
metK
Putative MetK, S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.929
STM4101
Putative aspartokinase II/homoserine dehydrogenase, methionine-sensitive; Predicted by orpheus program; predicted by glimmer program; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.909
Y3718
Putative aspartokinase I/homoserine dehydrogenase; Predicted by orpheus program; predicted by glimmer program; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.909
S2901
Putative autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
     
 0.904
Your Current Organism:
Photobacterium profundum
NCBI taxonomy Id: 298386
Other names: P. profundum SS9, Photobacterium SS9, Photobacterium profundum SS9, Photobacterium profundum str. SS9, Photobacterium profundum strain SS9, Photobacterium sp. (strain SS9), Photobacterium sp. SS9, deep-sea eubacterium SS9
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