STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ADP81919.1Hypothetical protein; KEGG: fal:FRAAL5353 putative ATP-dependent DNA helicase II. (133 aa)    
Predicted Functional Partners:
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.628
ADP81920.1
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: bcm:Bcenmc03_6918 short-chain dehydrogenase/reductase SDR.
   
 
 0.614
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
  
 
 0.556
ligA
DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
  
  
 0.535
ADP79856.1
DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; TIGRFAM: DNA polymerase III, epsilon subunit; KEGG: fal:FRAAL5108 hypothetical protein; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein.
  
  
 0.508
ADP84128.1
Helicase domain protein; KEGG: fal:FRAAL1185 putative ATP-dependent DNA helicase; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; phosphoribosyltransferase; SMART: DEAD-like helicase; helicase domain protein.
  
 
 0.501
ADP84684.1
KEGG: rer:RER_40510 hypothetical protein; PFAM: ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein.
  
 
 0.485
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.483
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.470
ADP78843.1
PFAM: UvrD/REP helicase; HRDC domain protein; KEGG: fal:FRAAL6038 putative ATP-dependent DNA helicase.
  
 
 0.459
Your Current Organism:
Frankia inefficax
NCBI taxonomy Id: 298654
Other names: CECT 9037, DSM 45817, F. inefficax, Frankia inefficax Nouioui et al. 2017, Frankia sp. EuI1c, strain EuI1c
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