SIM1 protein (Lonchura striata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

SIM1

Single-minded 1. (766 aa)

Predicted Functional Partners:

OTP

0.666

ARNT

0.665

ARNT2

0.665

MC4R

0.544

AGRP

0.537

TRH

0.537

FOXG1

0.530

LOC110471003

0.484

SUMO1

0.473

SCT

0.442

Your Current Organism:

Lonchura striata

NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	MC4R	ENSLSDP00000022112	ENSLSDP00000013971	Agouti-related protein.	Melanocortin receptor 4.	0.997
AGRP	SIM1	ENSLSDP00000022112	ENSLSDP00000000047	Agouti-related protein.	Single-minded 1.	0.537
AGRP	TRH	ENSLSDP00000022112	ENSLSDP00000023392	Agouti-related protein.	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.800
ARNT	OTP	ENSLSDP00000016630	ENSLSDP00000020324	Aryl hydrocarbon receptor nuclear translocator.	Homeobox protein orthopedia.	0.427
ARNT	SIM1	ENSLSDP00000016630	ENSLSDP00000000047	Aryl hydrocarbon receptor nuclear translocator.	Single-minded 1.	0.665
ARNT2	OTP	ENSLSDP00000024587	ENSLSDP00000020324	Aryl hydrocarbon receptor nuclear translocator 2.	Homeobox protein orthopedia.	0.427
ARNT2	SIM1	ENSLSDP00000024587	ENSLSDP00000000047	Aryl hydrocarbon receptor nuclear translocator 2.	Single-minded 1.	0.665
FOXG1	OTP	ENSLSDP00000000203	ENSLSDP00000020324	Forkhead box protein G1.	Homeobox protein orthopedia.	0.544
FOXG1	SIM1	ENSLSDP00000000203	ENSLSDP00000000047	Forkhead box protein G1.	Single-minded 1.	0.530
LOC110471003	SIM1	ENSLSDP00000005457	ENSLSDP00000000047	Cyclin-dependent kinase 7.	Single-minded 1.	0.484
MC4R	AGRP	ENSLSDP00000013971	ENSLSDP00000022112	Melanocortin receptor 4.	Agouti-related protein.	0.997
MC4R	SIM1	ENSLSDP00000013971	ENSLSDP00000000047	Melanocortin receptor 4.	Single-minded 1.	0.544
MC4R	TRH	ENSLSDP00000013971	ENSLSDP00000023392	Melanocortin receptor 4.	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.701
OTP	ARNT	ENSLSDP00000020324	ENSLSDP00000016630	Homeobox protein orthopedia.	Aryl hydrocarbon receptor nuclear translocator.	0.427
OTP	ARNT2	ENSLSDP00000020324	ENSLSDP00000024587	Homeobox protein orthopedia.	Aryl hydrocarbon receptor nuclear translocator 2.	0.427
OTP	FOXG1	ENSLSDP00000020324	ENSLSDP00000000203	Homeobox protein orthopedia.	Forkhead box protein G1.	0.544
OTP	SIM1	ENSLSDP00000020324	ENSLSDP00000000047	Homeobox protein orthopedia.	Single-minded 1.	0.666
OTP	TRH	ENSLSDP00000020324	ENSLSDP00000023392	Homeobox protein orthopedia.	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.530
SCT	SIM1	ENSLSDP00000005603	ENSLSDP00000000047	Secretin.	Single-minded 1.	0.442
SIM1	AGRP	ENSLSDP00000000047	ENSLSDP00000022112	Single-minded 1.	Agouti-related protein.	0.537