| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COQ10B | COQ2 | ENSLSDP00000001059 | ENSLSDP00000015439 | Coenzyme Q-binding protein COQ10 B, mitochondrial. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.523 |
| COQ10B | COQ3 | ENSLSDP00000001059 | ENSLSDP00000018375 | Coenzyme Q-binding protein COQ10 B, mitochondrial. | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | 0.499 |
| COQ10B | COQ4 | ENSLSDP00000001059 | ENSLSDP00000001097 | Coenzyme Q-binding protein COQ10 B, mitochondrial. | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 0.474 |
| COQ10B | COQ6 | ENSLSDP00000001059 | ENSLSDP00000003357 | Coenzyme Q-binding protein COQ10 B, mitochondrial. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.527 |
| COQ10B | COQ8A | ENSLSDP00000001059 | ENSLSDP00000014593 | Coenzyme Q-binding protein COQ10 B, mitochondrial. | Atypical kinase ADCK3, mitochondrial. | 0.589 |
| COQ10B | COQ9 | ENSLSDP00000001059 | ENSLSDP00000022411 | Coenzyme Q-binding protein COQ10 B, mitochondrial. | DNA-directed RNA polymerase II subunit RPB3. | 0.495 |
| COQ2 | COQ10B | ENSLSDP00000015439 | ENSLSDP00000001059 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Coenzyme Q-binding protein COQ10 B, mitochondrial. | 0.523 |
| COQ2 | COQ3 | ENSLSDP00000015439 | ENSLSDP00000018375 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | 0.792 |
| COQ2 | COQ4 | ENSLSDP00000015439 | ENSLSDP00000001097 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 0.662 |
| COQ2 | COQ6 | ENSLSDP00000015439 | ENSLSDP00000003357 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.901 |
| COQ2 | COQ8A | ENSLSDP00000015439 | ENSLSDP00000014593 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Atypical kinase ADCK3, mitochondrial. | 0.670 |
| COQ2 | COQ9 | ENSLSDP00000015439 | ENSLSDP00000022411 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | DNA-directed RNA polymerase II subunit RPB3. | 0.662 |
| COQ3 | COQ10B | ENSLSDP00000018375 | ENSLSDP00000001059 | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | Coenzyme Q-binding protein COQ10 B, mitochondrial. | 0.499 |
| COQ3 | COQ2 | ENSLSDP00000018375 | ENSLSDP00000015439 | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.792 |
| COQ3 | COQ4 | ENSLSDP00000018375 | ENSLSDP00000001097 | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 0.810 |
| COQ3 | COQ6 | ENSLSDP00000018375 | ENSLSDP00000003357 | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.947 |
| COQ3 | COQ8A | ENSLSDP00000018375 | ENSLSDP00000014593 | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | Atypical kinase ADCK3, mitochondrial. | 0.933 |
| COQ3 | COQ9 | ENSLSDP00000018375 | ENSLSDP00000022411 | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | DNA-directed RNA polymerase II subunit RPB3. | 0.791 |
| COQ4 | COQ10B | ENSLSDP00000001097 | ENSLSDP00000001059 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | Coenzyme Q-binding protein COQ10 B, mitochondrial. | 0.474 |
| COQ4 | COQ2 | ENSLSDP00000001097 | ENSLSDP00000015439 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.662 |