Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PCSK2Neuroendocrine convertase 2; Belongs to the peptidase S8 family. (581 aa)    
Predicted Functional Partners:
SCG5
Neuroendocrine protein 7B2.
   
 
 0.933
ENSLSDP00000025585
annotation not available
      
 0.874
PCSK9
Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.
      
 0.874
USP24
Ubiquitin carboxyl-terminal hydrolase 24; Belongs to the peptidase C19 family.
      
 0.874
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
     
 0.799
CPE
Carboxypeptidase E.
   
  
 0.632
PTPRN2
Receptor-type tyrosine-protein phosphatase N2.
   
  
 0.620
PTPRN
Protein tyrosine phosphatase receptor type N.
   
  
 0.620
UNC5B
Netrin receptor UNC5B.
      
 0.590
SPCS1
Signal peptidase complex subunit 1.
      
 0.588
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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