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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GSDMENon-syndromic hearing impairment protein 5. (501 aa)    
Predicted Functional Partners:
CASP3
Caspase-3; Belongs to the peptidase C14A family.
     
 0.732
LOC110474649
Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
     
 0.574
ENSLSDP00000015299
annotation not available
     
 0.574
MLKL
Mixed lineage kinase domain like pseudokinase.
      
 0.519
HMGB2
High mobility group protein B2.
     
 0.512
HMGB1
High mobility group protein B1.
     
 0.512
LOC110480577
Granzyme C.
     
 0.486
LOC110475732
Complement factor D; Belongs to the peptidase S1 family.
     
 0.486
PRSS57
Serine protease 57; Belongs to the peptidase S1 family.
     
 0.486
LOC110475735
Mast cell protease 1A; Belongs to the peptidase S1 family.
     
 0.486
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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