Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (276 aa)    
Predicted Functional Partners:
CDC25B
M-phase inducer phosphatase 2.
    
 0.959
YWHAE
14-3-3 protein epsilon; Belongs to the 14-3-3 family.
   
 0.918
YWHAB
14-3-3 protein beta/alpha; Belongs to the 14-3-3 family.
   
  0.907
YWHAZ
14-3-3 protein zeta; Belongs to the 14-3-3 family.
   
 0.892
BRAF
Serine/threonine-protein kinase B-raf.
    
 0.867
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.848
MAPT
Microtubule associated protein tau.
    
 
 0.844
TSC2
Tuberin.
    
 0.821
RAF1
RAF proto-oncogene serine/threonine-protein kinase.
    
 0.808
YWHAH
14-3-3 protein eta; Belongs to the 14-3-3 family.
   
  0.759
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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