Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NDRG1Protein NDRG1. (402 aa)    
Predicted Functional Partners:
NDRG4
Protein NDRG4-A.
    
   0.841
SLC7A5
Large neutral amino acids transporter small subunit 1.
   
 
 0.836
MYCN
N-myc proto-oncogene protein.
    
 
 0.741
LOC110484723
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 
 0.698
MYC
Myc proto-oncogene protein.
    
 
 0.665
VASH1
Vasohibin-1.
      
 0.659
LCP2
Lymphocyte cytosolic protein 2.
      
 0.592
AR
Androgen receptor.
    
 
 0.584
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.576
ARHGEF10
Rho guanine nucleotide exchange factor 10.
      
 0.573
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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