RNF169 protein (Lonchura striata) - STRING interaction network

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RNF169

E3 ubiquitin-protein ligase RNF169. (496 aa)

Predicted Functional Partners:

DYRK1A

0.895

DCAF7

0.891

USP7

0.883

FBXO38

0.870

RNF8

0.856

TP53BP1

0.855

UBA52

0.850

UBE2N

0.832

BRCA1

0.826

RNF168

0.825

Your Current Organism:

Lonchura striata

NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	RNF168	ENSLSDP00000008280	ENSLSDP00000023616	Breast cancer type 1 susceptibility.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	0.946
BRCA1	RNF169	ENSLSDP00000008280	ENSLSDP00000001750	Breast cancer type 1 susceptibility.	E3 ubiquitin-protein ligase RNF169.	0.826
BRCA1	RNF8	ENSLSDP00000008280	ENSLSDP00000014339	Breast cancer type 1 susceptibility.	E3 ubiquitin-protein ligase RNF8.	0.798
BRCA1	TP53BP1	ENSLSDP00000008280	ENSLSDP00000014242	Breast cancer type 1 susceptibility.	Tumor suppressor p53-binding protein 1.	0.994
BRCA1	UBE2N	ENSLSDP00000008280	ENSLSDP00000023659	Breast cancer type 1 susceptibility.	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.951
DCAF7	DYRK1A	ENSLSDP00000008388	ENSLSDP00000011266	DDB1-and CUL4-associated factor 7.	Dual specificity tyrosine-phosphorylation-regulated kinase 1A.	0.947
DCAF7	RNF168	ENSLSDP00000008388	ENSLSDP00000023616	DDB1-and CUL4-associated factor 7.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	0.606
DCAF7	RNF169	ENSLSDP00000008388	ENSLSDP00000001750	DDB1-and CUL4-associated factor 7.	E3 ubiquitin-protein ligase RNF169.	0.891
DYRK1A	DCAF7	ENSLSDP00000011266	ENSLSDP00000008388	Dual specificity tyrosine-phosphorylation-regulated kinase 1A.	DDB1-and CUL4-associated factor 7.	0.947
DYRK1A	RNF168	ENSLSDP00000011266	ENSLSDP00000023616	Dual specificity tyrosine-phosphorylation-regulated kinase 1A.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	0.637
DYRK1A	RNF169	ENSLSDP00000011266	ENSLSDP00000001750	Dual specificity tyrosine-phosphorylation-regulated kinase 1A.	E3 ubiquitin-protein ligase RNF169.	0.895
FBXO38	RNF168	ENSLSDP00000012215	ENSLSDP00000023616	F-box only protein 38.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	0.520
FBXO38	RNF169	ENSLSDP00000012215	ENSLSDP00000001750	F-box only protein 38.	E3 ubiquitin-protein ligase RNF169.	0.870
FBXO38	USP7	ENSLSDP00000012215	ENSLSDP00000010636	F-box only protein 38.	Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family.	0.907
RNF168	BRCA1	ENSLSDP00000023616	ENSLSDP00000008280	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	Breast cancer type 1 susceptibility.	0.946
RNF168	DCAF7	ENSLSDP00000023616	ENSLSDP00000008388	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	DDB1-and CUL4-associated factor 7.	0.606
RNF168	DYRK1A	ENSLSDP00000023616	ENSLSDP00000011266	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	Dual specificity tyrosine-phosphorylation-regulated kinase 1A.	0.637
RNF168	FBXO38	ENSLSDP00000023616	ENSLSDP00000012215	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	F-box only protein 38.	0.520
RNF168	RNF169	ENSLSDP00000023616	ENSLSDP00000001750	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	E3 ubiquitin-protein ligase RNF169.	0.825
RNF168	RNF8	ENSLSDP00000023616	ENSLSDP00000014339	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]	E3 ubiquitin-protein ligase RNF8.	0.923