| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALDH18A1 | DALRD3 | ENSLSDP00000020163 | ENSLSDP00000010675 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | DALR anticodon-binding domain-containing protein 3. | 0.470 |
| ALDH18A1 | GMPR | ENSLSDP00000020163 | ENSLSDP00000014773 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.470 |
| ALDH18A1 | GMPS | ENSLSDP00000020163 | ENSLSDP00000001879 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | GMP synthase [glutamine-hydrolyzing]. | 0.932 |
| ALDH18A1 | IMPDH1 | ENSLSDP00000020163 | ENSLSDP00000004686 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Inosine monophosphate dehydrogenase 1. | 0.470 |
| ALDH18A1 | IMPDH2 | ENSLSDP00000020163 | ENSLSDP00000010699 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.470 |
| DALRD3 | ALDH18A1 | ENSLSDP00000010675 | ENSLSDP00000020163 | DALR anticodon-binding domain-containing protein 3. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.470 |
| DALRD3 | GMPS | ENSLSDP00000010675 | ENSLSDP00000001879 | DALR anticodon-binding domain-containing protein 3. | GMP synthase [glutamine-hydrolyzing]. | 0.928 |
| GMPR | ALDH18A1 | ENSLSDP00000014773 | ENSLSDP00000020163 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.470 |
| GMPR | GMPS | ENSLSDP00000014773 | ENSLSDP00000001879 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | GMP synthase [glutamine-hydrolyzing]. | 0.992 |
| GMPR | GUK1 | ENSLSDP00000014773 | ENSLSDP00000011484 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Guanylate kinase. | 0.922 |
| GMPR | HPRT1 | ENSLSDP00000014773 | ENSLSDP00000007003 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.928 |
| GMPR | IMPDH1 | ENSLSDP00000014773 | ENSLSDP00000004686 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Inosine monophosphate dehydrogenase 1. | 0.926 |
| GMPR | IMPDH2 | ENSLSDP00000014773 | ENSLSDP00000010699 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.924 |
| GMPR | ITPA | ENSLSDP00000014773 | ENSLSDP00000013002 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.936 |
| GMPS | ALDH18A1 | ENSLSDP00000001879 | ENSLSDP00000020163 | GMP synthase [glutamine-hydrolyzing]. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.932 |
| GMPS | DALRD3 | ENSLSDP00000001879 | ENSLSDP00000010675 | GMP synthase [glutamine-hydrolyzing]. | DALR anticodon-binding domain-containing protein 3. | 0.928 |
| GMPS | GMPR | ENSLSDP00000001879 | ENSLSDP00000014773 | GMP synthase [glutamine-hydrolyzing]. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.992 |
| GMPS | GUK1 | ENSLSDP00000001879 | ENSLSDP00000011484 | GMP synthase [glutamine-hydrolyzing]. | Guanylate kinase. | 0.985 |
| GMPS | HPRT1 | ENSLSDP00000001879 | ENSLSDP00000007003 | GMP synthase [glutamine-hydrolyzing]. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.934 |
| GMPS | IMPDH1 | ENSLSDP00000001879 | ENSLSDP00000004686 | GMP synthase [glutamine-hydrolyzing]. | Inosine monophosphate dehydrogenase 1. | 0.995 |