Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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LOC110468281TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (559 aa)    
Predicted Functional Partners:
TGFB3
Transforming growth factor beta-3.
    
 0.993
TGFB2
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.991
TGFBR1
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
   
0.977
SMAD3
Mothers against decapentaplegic homolog.
   
 0.967
SMAD2
Mothers against decapentaplegic homolog.
   
 0.967
SMURF1
E3 ubiquitin-protein ligase.
    
 0.956
SMURF2
E3 ubiquitin-protein ligase.
    
 0.956
RHOA
Transforming protein RhoA.
   
 0.939
GDF15
Growth differentiation factor 15.
    
 0.927
ENSLSDP00000008873
Transforming growth factor beta-1 proprotein-like.
    
 0.926
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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