STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HSPB1Heat shock protein family B (small) member 1. (139 aa)    
Predicted Functional Partners:
MAPKAPK2
MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily.
   
 0.974
MAPKAPK5
MAP kinase-activated protein kinase 5.
    
 0.897
MAPKAPK3
MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily.
   
 0.889
BAG3
BAG family molecular chaperone regulator 3.
   
 
 0.790
CRYAB
Alpha-crystallin B chain; Belongs to the small heat shock protein (HSP20) family.
   
0.789
HSPA8
Heat shock cognate protein.
   
 0.765
HSPA2
Heat shock protein; Belongs to the heat shock protein 70 family.
   
 0.765
LDLRAD1
Low-density lipoprotein receptor class A domain-containing protein 1.
   
 0.741
TMEM59
Transmembrane protein 59.
   
 0.741
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.723
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.