Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HSPB1Heat shock protein family B (small) member 1. (139 aa)    
Predicted Functional Partners:
MAPKAPK2
MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily.
    
 0.993
MAPKAPK5
MAP kinase-activated protein kinase 5.
    
 0.987
MAPKAPK3
MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily.
    
 0.984
CRYAB
Alpha-crystallin B chain; Belongs to the small heat shock protein (HSP20) family.
   
 0.946
BAG3
BAG family molecular chaperone regulator 3.
   
 
 0.918
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.915
HSPA8
Heat shock cognate protein.
   
 0.902
HSPA2
Heat shock protein; Belongs to the heat shock protein 70 family.
   
 0.902
EFTUD2
U5 small nuclear ribonucleoprotein component.
    
 
 0.855
SF3B3
Splicing factor 3B subunit 3.
    
   0.850
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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