| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CH25H | COQ6 | ENSLSDP00000023820 | ENSLSDP00000003357 | Cholesterol 25-hydroxylase. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.504 |
| CH25H | KMO | ENSLSDP00000023820 | ENSLSDP00000004115 | Cholesterol 25-hydroxylase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.504 |
| CH25H | LOC110485022 | ENSLSDP00000023820 | ENSLSDP00000002997 | Cholesterol 25-hydroxylase. | Fatty acid desaturase 1. | 0.533 |
| CH25H | SC5D | ENSLSDP00000023820 | ENSLSDP00000025871 | Cholesterol 25-hydroxylase. | Lathosterol oxidase; Belongs to the sterol desaturase family. | 0.943 |
| CH25H | SQLE | ENSLSDP00000023820 | ENSLSDP00000000736 | Cholesterol 25-hydroxylase. | Squalene monooxygenase. | 0.934 |
| COQ6 | CH25H | ENSLSDP00000003357 | ENSLSDP00000023820 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Cholesterol 25-hydroxylase. | 0.504 |
| COQ6 | FAXDC2 | ENSLSDP00000003357 | ENSLSDP00000013879 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. | 0.504 |
| COQ6 | FDX1 | ENSLSDP00000003357 | ENSLSDP00000010553 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Adrenodoxin, mitochondrial. | 0.579 |
| COQ6 | FDX1_0 | ENSLSDP00000003357 | ENSLSDP00000007144 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Adrenodoxin, mitochondrial. | 0.579 |
| COQ6 | FDX2 | ENSLSDP00000003357 | ENSLSDP00000010359 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Ferredoxin-2, mitochondrial. | 0.579 |
| COQ6 | KMO | ENSLSDP00000003357 | ENSLSDP00000004115 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.556 |
| COQ6 | LOC110485022 | ENSLSDP00000003357 | ENSLSDP00000002997 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Fatty acid desaturase 1. | 0.414 |
| COQ6 | MSMO1 | ENSLSDP00000003357 | ENSLSDP00000018065 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. | 0.504 |
| COQ6 | SC5D | ENSLSDP00000003357 | ENSLSDP00000025871 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Lathosterol oxidase; Belongs to the sterol desaturase family. | 0.504 |
| FAXDC2 | COQ6 | ENSLSDP00000013879 | ENSLSDP00000003357 | Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.504 |
| FAXDC2 | KMO | ENSLSDP00000013879 | ENSLSDP00000004115 | Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. | 0.504 |
| FAXDC2 | LOC110485022 | ENSLSDP00000013879 | ENSLSDP00000002997 | Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. | Fatty acid desaturase 1. | 0.533 |
| FAXDC2 | SC5D | ENSLSDP00000013879 | ENSLSDP00000025871 | Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. | Lathosterol oxidase; Belongs to the sterol desaturase family. | 0.943 |
| FAXDC2 | SQLE | ENSLSDP00000013879 | ENSLSDP00000000736 | Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. | Squalene monooxygenase. | 0.934 |
| FDX1 | COQ6 | ENSLSDP00000010553 | ENSLSDP00000003357 | Adrenodoxin, mitochondrial. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.579 |