Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
AQP4Aquaporin-4 isoform X1. (337 aa)    
Predicted Functional Partners:
GFAP
Glial fibrillary acidic protein; Belongs to the intermediate filament family.
   
  
 0.899
CLDN5
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
  
 0.878
AQP11
Aquaporin-11; Belongs to the MIP/aquaporin (TC 1.A.8) family.
     
 0.790
LOC110475070
Aquaporin-7; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
  
0.760
AQP8
Aquaporin-8; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
 
0.724
ALDH1L2
10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
   
  
 0.711
CFTR
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
   
 
 0.697
IL1B
Interleukin-1; Belongs to the IL-1 family.
   
  
 0.676
AGT
Angiotensinogen; Belongs to the serpin family.
      
 0.673
LOC110483048
Aquaporin-12-like.
     
 0.664
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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