| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COQ2 | COQ3 | ENSLSDP00000015439 | ENSLSDP00000018375 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | 0.792 |
| COQ2 | FECH | ENSLSDP00000015439 | ENSLSDP00000023026 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.702 |
| COQ2 | ITIH5 | ENSLSDP00000015439 | ENSLSDP00000004580 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Inter-alpha-trypsin inhibitor heavy chain H5. | 0.444 |
| COQ3 | COQ2 | ENSLSDP00000018375 | ENSLSDP00000015439 | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.792 |
| COQ3 | FECH | ENSLSDP00000018375 | ENSLSDP00000023026 | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.673 |
| COQ3 | ITIH5 | ENSLSDP00000018375 | ENSLSDP00000004580 | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | Inter-alpha-trypsin inhibitor heavy chain H5. | 0.720 |
| COQ3 | PPOX | ENSLSDP00000018375 | ENSLSDP00000016727 | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | Protoporphyrinogen oxidase. | 0.681 |
| FECH | COQ2 | ENSLSDP00000023026 | ENSLSDP00000015439 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.702 |
| FECH | COQ3 | ENSLSDP00000023026 | ENSLSDP00000018375 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | 0.673 |
| FECH | ITIH5 | ENSLSDP00000023026 | ENSLSDP00000004580 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | Inter-alpha-trypsin inhibitor heavy chain H5. | 0.410 |
| FECH | PPOX | ENSLSDP00000023026 | ENSLSDP00000016727 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | Protoporphyrinogen oxidase. | 0.998 |
| GMPS | ITIH5 | ENSLSDP00000001879 | ENSLSDP00000004580 | GMP synthase [glutamine-hydrolyzing]. | Inter-alpha-trypsin inhibitor heavy chain H5. | 0.513 |
| GMPS | NT5E | ENSLSDP00000001879 | ENSLSDP00000019133 | GMP synthase [glutamine-hydrolyzing]. | Snake venom 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.922 |
| ITIH5 | COQ2 | ENSLSDP00000004580 | ENSLSDP00000015439 | Inter-alpha-trypsin inhibitor heavy chain H5. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.444 |
| ITIH5 | COQ3 | ENSLSDP00000004580 | ENSLSDP00000018375 | Inter-alpha-trypsin inhibitor heavy chain H5. | Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial. | 0.720 |
| ITIH5 | FECH | ENSLSDP00000004580 | ENSLSDP00000023026 | Inter-alpha-trypsin inhibitor heavy chain H5. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.410 |
| ITIH5 | GMPS | ENSLSDP00000004580 | ENSLSDP00000001879 | Inter-alpha-trypsin inhibitor heavy chain H5. | GMP synthase [glutamine-hydrolyzing]. | 0.513 |
| ITIH5 | NT5E | ENSLSDP00000004580 | ENSLSDP00000019133 | Inter-alpha-trypsin inhibitor heavy chain H5. | Snake venom 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.543 |
| ITIH5 | PPOX | ENSLSDP00000004580 | ENSLSDP00000016727 | Inter-alpha-trypsin inhibitor heavy chain H5. | Protoporphyrinogen oxidase. | 0.606 |
| NT5E | GMPS | ENSLSDP00000019133 | ENSLSDP00000001879 | Snake venom 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | GMP synthase [glutamine-hydrolyzing]. | 0.922 |