Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC110484567Gamma-secretase subunit PEN-2. (101 aa)    
Predicted Functional Partners:
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.991
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.991
NCSTN
Nicastrin.
    
 0.980
APH1A
Gamma-secretase subunit APH-1A.
    
 0.975
LOC110484179
Gamma-secretase subunit APH-1A.
    
 0.975
NOTCH1
Neurogenic locus notch 1.
    
 0.953
NOTCH2
Neurogenic locus notch 2.
    
 0.923
APP
Amyloid beta A4 protein.
    
 0.775
MME
Neprilysin.
      
 0.564
APLP2
Amyloid-like protein 2.
    
 0.526
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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