| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADSS1 | ADSS2 | ENSLSDP00000024021 | ENSLSDP00000014128 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.901 |
| ADSS1 | AMPD1 | ENSLSDP00000024021 | ENSLSDP00000001858 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.946 |
| ADSS1 | AMPD2 | ENSLSDP00000024021 | ENSLSDP00000012528 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.937 |
| ADSS1 | AMPD3 | ENSLSDP00000024021 | ENSLSDP00000025717 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.949 |
| ADSS1 | ATIC | ENSLSDP00000024021 | ENSLSDP00000017380 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Bifunctional purine biosynthesis protein PURH. | 0.991 |
| ADSS1 | GMPS | ENSLSDP00000024021 | ENSLSDP00000001879 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | GMP synthase [glutamine-hydrolyzing]. | 0.668 |
| ADSS1 | IMPDH1 | ENSLSDP00000024021 | ENSLSDP00000004686 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Inosine monophosphate dehydrogenase 1. | 0.966 |
| ADSS1 | NT5C | ENSLSDP00000024021 | ENSLSDP00000020471 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5', 3'-nucleotidase, cytosolic. | 0.930 |
| ADSS1 | NT5E | ENSLSDP00000024021 | ENSLSDP00000019133 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Snake venom 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.923 |
| ADSS1 | NT5M | ENSLSDP00000024021 | ENSLSDP00000009642 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5'(3')-deoxyribonucleotidase, mitochondrial. | 0.907 |
| ADSS2 | ADSS1 | ENSLSDP00000014128 | ENSLSDP00000024021 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 0.901 |
| ADSS2 | AMPD1 | ENSLSDP00000014128 | ENSLSDP00000001858 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.956 |
| ADSS2 | AMPD2 | ENSLSDP00000014128 | ENSLSDP00000012528 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.938 |
| ADSS2 | AMPD3 | ENSLSDP00000014128 | ENSLSDP00000025717 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.938 |
| ADSS2 | ATIC | ENSLSDP00000014128 | ENSLSDP00000017380 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Bifunctional purine biosynthesis protein PURH. | 0.995 |
| ADSS2 | GMPS | ENSLSDP00000014128 | ENSLSDP00000001879 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | GMP synthase [glutamine-hydrolyzing]. | 0.903 |
| ADSS2 | IMPDH1 | ENSLSDP00000014128 | ENSLSDP00000004686 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Inosine monophosphate dehydrogenase 1. | 0.976 |
| ADSS2 | NT5C | ENSLSDP00000014128 | ENSLSDP00000020471 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5', 3'-nucleotidase, cytosolic. | 0.913 |
| ADSS2 | NT5E | ENSLSDP00000014128 | ENSLSDP00000019133 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | Snake venom 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.923 |
| ADSS2 | NT5M | ENSLSDP00000014128 | ENSLSDP00000009642 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. | 5'(3')-deoxyribonucleotidase, mitochondrial. | 0.907 |