Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KIAA0319Dyslexia-associated protein KIAA0319. (1075 aa)    
Predicted Functional Partners:
AP2M1
AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family.
     
 0.586
DCDC2
Doublecortin domain-containing protein 2.
    
 
 0.577
C17orf75
Protein Njmu-R1.
      
 0.565
DNAAF4
Dyslexia susceptibility 1 candidate gene 1.
     
 0.546
AP2A2
AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
    
  0.488
ACOT13
Acyl-coenzyme A thioesterase 13.
      
 0.475
AP2S1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
     
  0.474
FAM91A1
Protein FAM91A1.
      
 0.471
UBQLN1
Ubiquilin-1.
    
  0.458
VAMP3
Vesicle-associated membrane protein 3.
     
  0.456
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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