FEN1 protein (Lonchura striata) - STRING interaction network

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FEN1

Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (386 aa)

Predicted Functional Partners:

PCNA

0.997

RAD50

0.992

APEX1

0.984

WRN

0.981

POLB

0.977

DNA2

0.970

RAD52

0.962

ATAD5

0.961

MRE11

0.960

MSH6

0.950

Your Current Organism:

Lonchura striata

NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	ATAD5	ENSLSDP00000011481	ENSLSDP00000021821	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	ATPase family AAA domain-containing protein 5.	0.581
APEX1	FEN1	ENSLSDP00000011481	ENSLSDP00000005343	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.984
APEX1	MRE11	ENSLSDP00000011481	ENSLSDP00000018865	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.443
APEX1	MSH6	ENSLSDP00000011481	ENSLSDP00000019559	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.560
APEX1	PCNA	ENSLSDP00000011481	ENSLSDP00000016329	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.958
APEX1	POLB	ENSLSDP00000011481	ENSLSDP00000009491	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.989
APEX1	RAD50	ENSLSDP00000011481	ENSLSDP00000010464	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA repair protein RAD50.	0.445
APEX1	RAD52	ENSLSDP00000011481	ENSLSDP00000025235	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA repair protein RAD52.	0.508
APEX1	WRN	ENSLSDP00000011481	ENSLSDP00000017027	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Werner syndrome ATP-dependent helicase.	0.532
ATAD5	APEX1	ENSLSDP00000021821	ENSLSDP00000011481	ATPase family AAA domain-containing protein 5.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.581
ATAD5	DNA2	ENSLSDP00000021821	ENSLSDP00000024632	ATPase family AAA domain-containing protein 5.	DNA replication ATP-dependent helicase/nuclease DNA2.	0.882
ATAD5	FEN1	ENSLSDP00000021821	ENSLSDP00000005343	ATPase family AAA domain-containing protein 5.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.961
ATAD5	MRE11	ENSLSDP00000021821	ENSLSDP00000018865	ATPase family AAA domain-containing protein 5.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.922
ATAD5	MSH6	ENSLSDP00000021821	ENSLSDP00000019559	ATPase family AAA domain-containing protein 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.562
ATAD5	PCNA	ENSLSDP00000021821	ENSLSDP00000016329	ATPase family AAA domain-containing protein 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.979
ATAD5	RAD50	ENSLSDP00000021821	ENSLSDP00000010464	ATPase family AAA domain-containing protein 5.	DNA repair protein RAD50.	0.878
ATAD5	RAD52	ENSLSDP00000021821	ENSLSDP00000025235	ATPase family AAA domain-containing protein 5.	DNA repair protein RAD52.	0.904
ATAD5	WRN	ENSLSDP00000021821	ENSLSDP00000017027	ATPase family AAA domain-containing protein 5.	Werner syndrome ATP-dependent helicase.	0.871
DNA2	ATAD5	ENSLSDP00000024632	ENSLSDP00000021821	DNA replication ATP-dependent helicase/nuclease DNA2.	ATPase family AAA domain-containing protein 5.	0.882
DNA2	FEN1	ENSLSDP00000024632	ENSLSDP00000005343	DNA replication ATP-dependent helicase/nuclease DNA2.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.970

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