HYAL protein (Lonchura striata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

HYAL

Hyaluronidase. (546 aa)

Predicted Functional Partners:

IDUA

0.917

GUSB

0.917

ARSB

0.905

GAK

0.609

ITSN2

0.596

PLD1

0.580

GBF1

0.580

COPB1

0.573

ARFGAP1

0.572

COPB2

0.570

Your Current Organism:

Lonchura striata

NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARFGAP1	COPB1	ENSLSDP00000008258	ENSLSDP00000025792	ADP-ribosylation factor GTPase-activating protein 1.	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.705
ARFGAP1	COPB2	ENSLSDP00000008258	ENSLSDP00000021597	ADP-ribosylation factor GTPase-activating protein 1.	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.738
ARFGAP1	GBF1	ENSLSDP00000008258	ENSLSDP00000004645	ADP-ribosylation factor GTPase-activating protein 1.	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1.	0.850
ARFGAP1	HYAL	ENSLSDP00000008258	ENSLSDP00000005356	ADP-ribosylation factor GTPase-activating protein 1.	Hyaluronidase.	0.572
ARFGAP1	ITSN2	ENSLSDP00000008258	ENSLSDP00000003205	ADP-ribosylation factor GTPase-activating protein 1.	Intersectin-2.	0.564
ARSB	HYAL	ENSLSDP00000012697	ENSLSDP00000005356	Arylsulfatase B.	Hyaluronidase.	0.905
ARSB	IDUA	ENSLSDP00000012697	ENSLSDP00000015958	Arylsulfatase B.	Alpha-L-iduronidase.	0.940
COPB1	ARFGAP1	ENSLSDP00000025792	ENSLSDP00000008258	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	ADP-ribosylation factor GTPase-activating protein 1.	0.705
COPB1	COPB2	ENSLSDP00000025792	ENSLSDP00000021597	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.999
COPB1	GBF1	ENSLSDP00000025792	ENSLSDP00000004645	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1.	0.810
COPB1	HYAL	ENSLSDP00000025792	ENSLSDP00000005356	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Hyaluronidase.	0.573
COPB2	ARFGAP1	ENSLSDP00000021597	ENSLSDP00000008258	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	ADP-ribosylation factor GTPase-activating protein 1.	0.738
COPB2	COPB1	ENSLSDP00000021597	ENSLSDP00000025792	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.999
COPB2	GBF1	ENSLSDP00000021597	ENSLSDP00000004645	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1.	0.755
COPB2	HYAL	ENSLSDP00000021597	ENSLSDP00000005356	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	Hyaluronidase.	0.570
GAK	HYAL	ENSLSDP00000000568	ENSLSDP00000005356	Cyclin-G-associated kinase.	Hyaluronidase.	0.609
GAK	ITSN2	ENSLSDP00000000568	ENSLSDP00000003205	Cyclin-G-associated kinase.	Intersectin-2.	0.942
GBF1	ARFGAP1	ENSLSDP00000004645	ENSLSDP00000008258	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1.	ADP-ribosylation factor GTPase-activating protein 1.	0.850
GBF1	COPB1	ENSLSDP00000004645	ENSLSDP00000025792	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1.	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.810
GBF1	COPB2	ENSLSDP00000004645	ENSLSDP00000021597	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1.	Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	0.755