Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTCH1Protein patched 1. (1432 aa)    
Predicted Functional Partners:
SMO
Smoothened; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.999
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.997
IHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.993
DHH
Desert hedgehog protein.
   
 0.990
CDON
Cell adhesion molecule-related protein.
    
 0.988
BOC
Brother of CDO.
    
 0.984
SMURF1
E3 ubiquitin-protein ligase.
    
 0.977
SMURF2
E3 ubiquitin-protein ligase.
    
 0.977
GAS1
Growth arrest-specific protein 1.
     
 0.956
GLI3
Transcriptional activator GLI3.
   
 0.949
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.