Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
GNASGuanine nucleotide-binding protein G(S) subunit alpha. (414 aa)    
Predicted Functional Partners:
ADCY9
Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
    
 0.992
ADCY8
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
   
 0.989
LOC110477391
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
   
 0.982
ADCY7
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
   
 0.966
ADCY2
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
   
 0.966
ADCY6
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
   
 0.965
ADCY5
Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
   
 0.965
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
    
 0.955
ADRB1
Adrenergic receptor beta-1.
    
 0.948
ADRB2
Beta-2 adrenergic receptor.
    
 0.948
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
Server load: low (10%) [HD]