Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADAM22Disintegrin and metalloproteinase domain-containing protein 22. (921 aa)    
Predicted Functional Partners:
LGI2
Leucine-rich repeat LGI family member 2.
     
 0.969
ENSLSDP00000002880
LOW QUALITY PROTEIN: leucine-rich repeat LGI family member 4-like.
   
 0.928
LGI1
Leucine-rich glioma-inactivated protein 1.
   
 0.928
YWHAZ
14-3-3 protein zeta; Belongs to the 14-3-3 family.
    
   0.842
ADAM23
Disintegrin and metalloproteinase domain-containing protein 23.
   
 0.808
CACNG2
Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
   
 
 0.763
NFASC
Neurofascin.
   
  
 0.717
ENSLSDP00000022057
annotation not available
   
 
 0.618
LGI3
Leucine-rich repeat LGI family member 3.
   
 
 0.618
GUK1
Guanylate kinase.
    
 0.609
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.