Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HPS6Hermansky-Pudlak syndrome 6. (754 aa)    
Predicted Functional Partners:
HPS3
Hermansky-Pudlak syndrome 3 protein.
   
 0.990
HPS5
Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
    
 0.986
APPBP2
Amyloid protein-binding protein 2.
      
 0.873
BLOC1S3
Biogenesis of lysosome-related organelles complex 1 subunit 3.
     
 0.858
BLOC1S4
Biogenesis of lysosome-related organelles complex 1 subunit 4.
     
 0.858
BLOC1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]
     
 0.851
TYRP1
5,6-dihydroxyindole-2-carboxylic acid oxidase.
      
 0.786
HPS1
Hermansky-Pudlak syndrome 1 protein.
     
 0.726
BLOC1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5.
     
 0.720
DTNBP1
Dysbindin.
   
 
 0.676
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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