STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSRTyrosine-protein kinase receptor. (1365 aa)    
Predicted Functional Partners:
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.990
PTPN1
Tyrosine-protein phosphatase non-receptor type.
   
 0.980
IRS4
Insulin receptor substrate 2-A.
    
 0.972
IRS1
Insulin receptor substrate 1.
    
 0.972
IRS2
Insulin receptor substrate 2.
    
 0.972
SHC1
SHC-transforming protein 1.
    
 0.965
GRB2
Growth factor receptor-bound protein 2.
   
 0.954
GRB10
Growth factor receptor-bound protein 10.
    
 0.946
IGF1
Insulin-like growth factor I.
     
 0.941
IGF2
Insulin-like growth factor II.
    
 0.935
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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