Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HEPHHephaestin; Belongs to the multicopper oxidase family. (555 aa)    
Predicted Functional Partners:
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
   
 
 0.928
FXN
Frataxin, mitochondrial.
     
 0.914
HEPHL1
Hephaestin-like protein 1; Belongs to the multicopper oxidase family.
  
  
 
0.908
FTH1
Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
     
 0.908
HMOX1
Heme oxygenase 1.
     
 0.907
HMOX2
Heme oxygenase 2.
     
 0.907
LOC110481429
Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
     
 0.907
CP
Ceruloplasmin; Belongs to the multicopper oxidase family.
  
  
 
0.903
SLC40A1
Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
    
 0.646
FAM20C
Extracellular serine/threonine protein kinase FAM20C.
    
  0.432
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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