Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
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[Homology]
Score
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (358 aa)    
Predicted Functional Partners:
TJP1
Tight junction protein ZO-1; Belongs to the MAGUK family.
   
 0.918
TJP3
Tight junction protein ZO-3; Belongs to the MAGUK family.
   
 0.914
PARD3
Partitioning defective 3.
     
  0.900
ITGA4
Integrin alpha-4; Belongs to the integrin alpha chain family.
   
  
 0.879
PDCD4
Programmed cell death protein 4.
      
 0.730
PLK1
Serine/threonine-protein kinase PLK.
      
 0.719
MUC1
Mucin-1.
      
 0.719
CLDN1
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
    
0.710
CLDN19
Claudin 19.
    
0.710
CLDN23
Claudin-23.
     
 0.707
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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