Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (157 aa)    
Predicted Functional Partners:
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
    
 0.972
MAP3K4
Mitogen-activated protein kinase kinase kinase 4.
    
 0.952
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 
 0.920
CDK1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
    
  0.908
CCNB3
G2/mitotic-specific cyclin-B3; Belongs to the cyclin family.
    
 0.904
GADD45B
Growth arrest and DNA damage-inducible protein GADD45 beta.
  
  
 
0.903
GADD45G
Growth arrest and DNA damage-inducible protein GADD45 gamma.
  
  
 
0.901
CCNB2
G2/mitotic-specific cyclin-B2; Belongs to the cyclin family.
    
  0.900
AURKA
Aurora kinase A; Belongs to the protein kinase superfamily.
     
  0.588
LOC110483774
Aurora kinase B.
     
  0.588
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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