| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BMT2 | C12orf66 | ENSLSDP00000001603 | ENSLSDP00000022807 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | UPF0536 protein C12orf66. | 0.971 |
| BMT2 | DEPDC5 | ENSLSDP00000001603 | ENSLSDP00000000710 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | DEP domain-containing protein 5. | 0.974 |
| BMT2 | ENSLSDP00000007557 | ENSLSDP00000001603 | ENSLSDP00000007557 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | annotation not available | 0.951 |
| BMT2 | ITFG2 | ENSLSDP00000001603 | ENSLSDP00000017540 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Integrin-alpha FG-GAP repeat-containing protein 2. | 0.968 |
| BMT2 | MIOS | ENSLSDP00000001603 | ENSLSDP00000024986 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | WD repeat-containing protein mio. | 0.473 |
| BMT2 | NPRL2 | ENSLSDP00000001603 | ENSLSDP00000025084 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Nitrogen permease regulator 2-like protein. | 0.890 |
| BMT2 | NPRL3 | ENSLSDP00000001603 | ENSLSDP00000006331 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Nitrogen permease regulator 3-like protein. | 0.890 |
| BMT2 | WDR24 | ENSLSDP00000001603 | ENSLSDP00000002732 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | WD repeat-containing protein 24. | 0.413 |
| BMT2 | WDR59 | ENSLSDP00000001603 | ENSLSDP00000021979 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | WD repeat-containing protein 59. | 0.437 |
| C12orf66 | BMT2 | ENSLSDP00000022807 | ENSLSDP00000001603 | UPF0536 protein C12orf66. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.971 |
| C12orf66 | DEPDC5 | ENSLSDP00000022807 | ENSLSDP00000000710 | UPF0536 protein C12orf66. | DEP domain-containing protein 5. | 0.984 |
| C12orf66 | ENSLSDP00000007557 | ENSLSDP00000022807 | ENSLSDP00000007557 | UPF0536 protein C12orf66. | annotation not available | 0.995 |
| C12orf66 | ITFG2 | ENSLSDP00000022807 | ENSLSDP00000017540 | UPF0536 protein C12orf66. | Integrin-alpha FG-GAP repeat-containing protein 2. | 0.999 |
| C12orf66 | MIOS | ENSLSDP00000022807 | ENSLSDP00000024986 | UPF0536 protein C12orf66. | WD repeat-containing protein mio. | 0.779 |
| C12orf66 | NPRL2 | ENSLSDP00000022807 | ENSLSDP00000025084 | UPF0536 protein C12orf66. | Nitrogen permease regulator 2-like protein. | 0.982 |
| C12orf66 | NPRL3 | ENSLSDP00000022807 | ENSLSDP00000006331 | UPF0536 protein C12orf66. | Nitrogen permease regulator 3-like protein. | 0.909 |
| C12orf66 | SEH1L | ENSLSDP00000022807 | ENSLSDP00000019610 | UPF0536 protein C12orf66. | Nucleoporin SEH1; Belongs to the WD repeat SEC13 family. | 0.739 |
| C12orf66 | WDR24 | ENSLSDP00000022807 | ENSLSDP00000002732 | UPF0536 protein C12orf66. | WD repeat-containing protein 24. | 0.993 |
| C12orf66 | WDR59 | ENSLSDP00000022807 | ENSLSDP00000021979 | UPF0536 protein C12orf66. | WD repeat-containing protein 59. | 0.981 |
| DEPDC5 | BMT2 | ENSLSDP00000000710 | ENSLSDP00000001603 | DEP domain-containing protein 5. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.974 |