Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ZSWIM8Zinc finger SWIM domain-containing protein 8. (1822 aa)    
Predicted Functional Partners:
ELOC
Transcription elongation factor B polypeptide 1; Belongs to the SKP1 family.
    
 0.907
CUL3
Cullin-3; Belongs to the cullin family.
    
 
 0.784
AGO2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
 
 0.781
ELOB
Transcription elongation factor B polypeptide 2.
    
 0.679
ECM1
Extracellular matrix protein 1.
      
 0.676
MRPS14
28S ribosomal protein S14, mitochondrial.
      
 0.599
CUL2
Cullin-2; Belongs to the cullin family.
     
 0.590
LOC110474354
Transcription initiation factor TFIID subunit 9.
      
 0.575
RBX1
E3 ubiquitin-protein ligase RBX1.
     
 0.571
ZBTB44
Zinc finger and BTB domain-containing protein 44.
      
 0.568
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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