STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOPBP1DNA topoisomerase 2-binding protein 1. (1520 aa)    
Predicted Functional Partners:
BRIP1
Fanconi anemia group J.
   
 0.997
TP53BP1
Tumor suppressor p53-binding protein 1.
    
 
 0.990
CDC45
Cell division control protein 45.
   
 
 0.989
RAD9B
Cell cycle checkpoint control protein; Belongs to the rad9 family.
    
 0.981
ATR
Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
    
 0.980
WRN
Werner syndrome ATP-dependent helicase.
   
 0.980
BRCA1
Breast cancer type 1 susceptibility.
   
 0.979
BARD1
BRCA1-associated RING domain protein 1.
   
 0.971
MCM5
DNA helicase; Belongs to the MCM family.
   
 
 0.959
MCM3
DNA helicase; Belongs to the MCM family.
   
 
 0.940
Your Current Organism:
Lonchura striata
NCBI taxonomy Id: 299123
Other names: Bengalese finch, L. striata domestica, Lonchura domestica, Lonchura striata domestica, society finch
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.