node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDK1 | NCAPH | ENSLSDP00000019252 | ENSLSDP00000005234 | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. | Condensin complex subunit 2. | 0.516 |
CDK1 | PCNA | ENSLSDP00000019252 | ENSLSDP00000016329 | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.646 |
CDK1 | SMC2 | ENSLSDP00000019252 | ENSLSDP00000013582 | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. | Structural maintenance of chromosomes protein 2. | 0.731 |
CDK1 | SMC4 | ENSLSDP00000019252 | ENSLSDP00000010578 | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. | Structural maintenance of chromosomes protein. | 0.723 |
CDK1 | TOP2A | ENSLSDP00000019252 | ENSLSDP00000010096 | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.763 |
KCTD9 | TOP2A | ENSLSDP00000002920 | ENSLSDP00000010096 | BTB/POZ domain-containing protein KCTD9. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.804 |
NCAPH | CDK1 | ENSLSDP00000005234 | ENSLSDP00000019252 | Condensin complex subunit 2. | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. | 0.516 |
NCAPH | SMC2 | ENSLSDP00000005234 | ENSLSDP00000013582 | Condensin complex subunit 2. | Structural maintenance of chromosomes protein 2. | 0.999 |
NCAPH | SMC4 | ENSLSDP00000005234 | ENSLSDP00000010578 | Condensin complex subunit 2. | Structural maintenance of chromosomes protein. | 0.999 |
NCAPH | SMC6 | ENSLSDP00000005234 | ENSLSDP00000000178 | Condensin complex subunit 2. | Structural maintenance of chromosomes protein 6. | 0.853 |
NCAPH | TOP2A | ENSLSDP00000005234 | ENSLSDP00000010096 | Condensin complex subunit 2. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.758 |
PCNA | CDK1 | ENSLSDP00000016329 | ENSLSDP00000019252 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. | 0.646 |
PCNA | SMC2 | ENSLSDP00000016329 | ENSLSDP00000013582 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Structural maintenance of chromosomes protein 2. | 0.520 |
PCNA | SMC4 | ENSLSDP00000016329 | ENSLSDP00000010578 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Structural maintenance of chromosomes protein. | 0.505 |
PCNA | TOP1 | ENSLSDP00000016329 | ENSLSDP00000019706 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.434 |
PCNA | TOP1MT | ENSLSDP00000016329 | ENSLSDP00000019208 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] | 0.434 |
PCNA | TOP2A | ENSLSDP00000016329 | ENSLSDP00000010096 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. | 0.743 |
PCNA | YARS1 | ENSLSDP00000016329 | ENSLSDP00000006125 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Tyrosine--tRNA ligase. | 0.683 |
SMC2 | CDK1 | ENSLSDP00000013582 | ENSLSDP00000019252 | Structural maintenance of chromosomes protein 2. | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. | 0.731 |
SMC2 | NCAPH | ENSLSDP00000013582 | ENSLSDP00000005234 | Structural maintenance of chromosomes protein 2. | Condensin complex subunit 2. | 0.999 |