node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATM | BRCA1 | ENSLSDP00000024899 | ENSLSDP00000008280 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | Breast cancer type 1 susceptibility. | 0.990 |
ATM | EXO1 | ENSLSDP00000024899 | ENSLSDP00000019858 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | Exonuclease 1. | 0.845 |
ATM | FEN1 | ENSLSDP00000024899 | ENSLSDP00000005343 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.593 |
ATM | MRE11 | ENSLSDP00000024899 | ENSLSDP00000018865 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.995 |
ATM | NBN | ENSLSDP00000024899 | ENSLSDP00000002612 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.996 |
ATM | RAD50 | ENSLSDP00000024899 | ENSLSDP00000010464 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | DNA repair protein RAD50. | 0.992 |
ATM | RBBP8-2 | ENSLSDP00000024899 | ENSLSDP00000005084 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | DNA endonuclease RBBP8. | 0.670 |
ATM | WRN | ENSLSDP00000024899 | ENSLSDP00000017027 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | Werner syndrome ATP-dependent helicase. | 0.988 |
ATM | XRCC5 | ENSLSDP00000024899 | ENSLSDP00000017946 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.849 |
ATM | XRCC6 | ENSLSDP00000024899 | ENSLSDP00000003169 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | X-ray repair cross-complementing protein 5. | 0.878 |
BRCA1 | ATM | ENSLSDP00000008280 | ENSLSDP00000024899 | Breast cancer type 1 susceptibility. | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. | 0.990 |
BRCA1 | EXO1 | ENSLSDP00000008280 | ENSLSDP00000019858 | Breast cancer type 1 susceptibility. | Exonuclease 1. | 0.865 |
BRCA1 | FEN1 | ENSLSDP00000008280 | ENSLSDP00000005343 | Breast cancer type 1 susceptibility. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.496 |
BRCA1 | MRE11 | ENSLSDP00000008280 | ENSLSDP00000018865 | Breast cancer type 1 susceptibility. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.982 |
BRCA1 | NBN | ENSLSDP00000008280 | ENSLSDP00000002612 | Breast cancer type 1 susceptibility. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.916 |
BRCA1 | RAD50 | ENSLSDP00000008280 | ENSLSDP00000010464 | Breast cancer type 1 susceptibility. | DNA repair protein RAD50. | 0.944 |
BRCA1 | RBBP8-2 | ENSLSDP00000008280 | ENSLSDP00000005084 | Breast cancer type 1 susceptibility. | DNA endonuclease RBBP8. | 0.996 |
BRCA1 | WRN | ENSLSDP00000008280 | ENSLSDP00000017027 | Breast cancer type 1 susceptibility. | Werner syndrome ATP-dependent helicase. | 0.901 |
BRCA1 | XRCC5 | ENSLSDP00000008280 | ENSLSDP00000017946 | Breast cancer type 1 susceptibility. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.672 |
BRCA1 | XRCC6 | ENSLSDP00000008280 | ENSLSDP00000003169 | Breast cancer type 1 susceptibility. | X-ray repair cross-complementing protein 5. | 0.642 |