node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHH21527.1 | apt | SAMN02745129_1491 | SAMN02745129_1669 | CBS domain-containing protein. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.731 |
SHH21527.1 | gmk | SAMN02745129_1491 | SAMN02745129_0093 | CBS domain-containing protein. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.402 |
SHH21527.1 | guaA | SAMN02745129_1491 | SAMN02745129_1850 | CBS domain-containing protein. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.986 |
SHH21527.1 | guaB | SAMN02745129_1491 | SAMN02745129_1851 | CBS domain-containing protein. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.613 |
SHH21527.1 | guaC | SAMN02745129_1491 | SAMN02745129_0330 | CBS domain-containing protein. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.613 |
SHH21527.1 | purL | SAMN02745129_1491 | SAMN02745129_1752 | CBS domain-containing protein. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.686 |
apt | SHH21527.1 | SAMN02745129_1669 | SAMN02745129_1491 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CBS domain-containing protein. | 0.731 |
apt | argS | SAMN02745129_1669 | SAMN02745129_3807 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | arginyl-tRNA synthetase. | 0.419 |
apt | gmk | SAMN02745129_1669 | SAMN02745129_0093 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.977 |
apt | guaA | SAMN02745129_1669 | SAMN02745129_1850 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.993 |
apt | guaB | SAMN02745129_1669 | SAMN02745129_1851 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.638 |
apt | guaC | SAMN02745129_1669 | SAMN02745129_0330 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.888 |
apt | purL | SAMN02745129_1669 | SAMN02745129_1752 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.910 |
apt | pyrG | SAMN02745129_1669 | SAMN02745129_0568 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.788 |
apt | rpsM | SAMN02745129_1669 | SAMN02745129_0529 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Small subunit ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. | 0.622 |
argS | apt | SAMN02745129_3807 | SAMN02745129_1669 | arginyl-tRNA synthetase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.419 |
argS | gmk | SAMN02745129_3807 | SAMN02745129_0093 | arginyl-tRNA synthetase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.692 |
argS | guaA | SAMN02745129_3807 | SAMN02745129_1850 | arginyl-tRNA synthetase. | GMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. | 0.977 |
argS | guaC | SAMN02745129_3807 | SAMN02745129_0330 | arginyl-tRNA synthetase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.487 |
argS | purL | SAMN02745129_3807 | SAMN02745129_1752 | arginyl-tRNA synthetase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.755 |