node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHH78209.1 | SHH80097.1 | SAMN02745129_2960 | SAMN02745129_3057 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.985 |
SHH78209.1 | SHH94310.1 | SAMN02745129_2960 | SAMN02745129_3191 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase A. | 0.904 |
SHH78209.1 | SHI04929.1 | SAMN02745129_2960 | SAMN02745129_3817 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.985 |
SHH78209.1 | SHI04944.1 | SAMN02745129_2960 | SAMN02745129_3818 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.998 |
SHH78209.1 | SHI08235.1 | SAMN02745129_2960 | SAMN02745129_3945 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine-gamma-lyase. | 0.981 |
SHH78209.1 | SHI15930.1 | SAMN02745129_2960 | SAMN02745129_4507 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.904 |
SHH78209.1 | SHI19820.1 | SAMN02745129_2960 | SAMN02745129_4749 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cysteine synthase A. | 0.904 |
SHH78209.1 | metAS | SAMN02745129_2960 | SAMN02745129_2892 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.920 |
SHH78209.1 | metG | SAMN02745129_2960 | SAMN02745129_1070 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.905 |
SHH78209.1 | metK | SAMN02745129_2960 | SAMN02745129_3004 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.957 |
SHH80097.1 | SHH78209.1 | SAMN02745129_3057 | SAMN02745129_2960 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.985 |
SHH80097.1 | SHH94310.1 | SAMN02745129_3057 | SAMN02745129_3191 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cysteine synthase A. | 0.862 |
SHH80097.1 | SHI04929.1 | SAMN02745129_3057 | SAMN02745129_3817 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.996 |
SHH80097.1 | SHI04944.1 | SAMN02745129_3057 | SAMN02745129_3818 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.986 |
SHH80097.1 | SHI08235.1 | SAMN02745129_3057 | SAMN02745129_3945 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine-gamma-lyase. | 0.968 |
SHH80097.1 | SHI15930.1 | SAMN02745129_3057 | SAMN02745129_4507 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.862 |
SHH80097.1 | SHI19820.1 | SAMN02745129_3057 | SAMN02745129_4749 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Cysteine synthase A. | 0.862 |
SHH80097.1 | metAS | SAMN02745129_3057 | SAMN02745129_2892 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.988 |
SHH80097.1 | metG | SAMN02745129_3057 | SAMN02745129_1070 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.579 |
SHH80097.1 | metK | SAMN02745129_3057 | SAMN02745129_3004 | Aspartate kinase; In the C-terminal section; belongs to the homoserine dehydrogenase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.821 |