APX10922.1 protein (Tateyamaria omphalii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

APX10922.1

Peptidase S15; Derived by automated computational analysis using gene prediction method: Protein Homology. (650 aa)

Predicted Functional Partners:

APX10921.1

0.753

APX10918.1

0.579

APX10916.1

0.577

APX10919.1

0.572

APX10920.1

0.482

APX10923.1

0.411

Your Current Organism:

Tateyamaria omphalii

NCBI taxonomy Id: 299262
Other names: IAM 15108, JCM 21569, KCTC 12333, T. omphalii, Tateyamaria omphalii Kurahashi and Yokota 2008 emend. Sass et al. 2010, strain MKT107

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APX10916.1	APX10918.1	BWR18_03830	BWR18_03840	Nucleotide pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.729
APX10916.1	APX10919.1	BWR18_03830	BWR18_03845	Nucleotide pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.615
APX10916.1	APX10920.1	BWR18_03830	BWR18_03850	Nucleotide pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
APX10916.1	APX10921.1	BWR18_03830	BWR18_03855	Nucleotide pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.741
APX10916.1	APX10922.1	BWR18_03830	BWR18_03860	Nucleotide pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptidase S15; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.577
APX10918.1	APX10916.1	BWR18_03840	BWR18_03830	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Nucleotide pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.729
APX10918.1	APX10919.1	BWR18_03840	BWR18_03845	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
APX10918.1	APX10920.1	BWR18_03840	BWR18_03850	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.924
APX10918.1	APX10921.1	BWR18_03840	BWR18_03855	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Peptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.867
APX10918.1	APX10922.1	BWR18_03840	BWR18_03860	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	Peptidase S15; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.579
APX10919.1	APX10916.1	BWR18_03845	BWR18_03830	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotide pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.615
APX10919.1	APX10918.1	BWR18_03845	BWR18_03840	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.990
APX10919.1	APX10920.1	BWR18_03845	BWR18_03850	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.975
APX10919.1	APX10921.1	BWR18_03845	BWR18_03855	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
APX10919.1	APX10922.1	BWR18_03845	BWR18_03860	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptidase S15; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.572
APX10920.1	APX10916.1	BWR18_03850	BWR18_03830	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotide pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.500
APX10920.1	APX10918.1	BWR18_03850	BWR18_03840	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ABC transporter superfamily.	0.924
APX10920.1	APX10919.1	BWR18_03850	BWR18_03845	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.975
APX10920.1	APX10921.1	BWR18_03850	BWR18_03855	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.925
APX10920.1	APX10922.1	BWR18_03850	BWR18_03860	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptidase S15; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.482

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.879

expected number of edges:

13

PPI enrichment p-value:

1.39e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0052621

Diguanylate cyclase activity

8 of 12

2.69

8.26

3.94e-17

GO:0071111

Cyclic-guanylate-specific phosphodiesterase activity

3 of 5

2.65

2.5

2.33e-05

GO:0042578

Phosphoric ester hydrolase activity

4 of 58

1.71

1.68

0.00018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

8 of 1351

0.64

0.47

0.0047

GO:0016020

Membrane

11 of 2949

0.44

0.36

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8019

Diguanylate cyclase, and His Kinase A (phosphoacceptor) domain

11 of 21

2.59

11.15

8.91e-25

CL:8027

Putative diguanylate phosphodiesterase, and Histidine kinase-like ATPase domain

6 of 11

2.61

5.93

2.30e-12

CL:8028

Putative diguanylate phosphodiesterase

4 of 6

2.69

3.88

5.21e-08

CL:8039

Mixed, incl. Histidine kinase-like ATPase domain, and Cyclic-guanylate-specific phosphodiesterase activity

2 of 5

2.47

1.28

0.0045

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

6 of 533

0.92

0.69

0.0041

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005886

Plasma membrane

8 of 834

0.85

0.73

0.00052

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00267

Diguanylate cyclase

9 of 16

2.62

9.37

4.58e-20

SM00052

Putative diguanylate phosphodiesterase

5 of 9

2.61

4.96

2.73e-10

SM00091

PAS domain

3 of 8

2.44

2.51

1.77e-05

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 6

2.39

1.45

0.0020

SM00065

Domain present in phytochromes and cGMP-specific phosphodiesterases.

2 of 15

1.99

1.1

0.0079

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