APX11115.1 protein (Tateyamaria omphalii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

APX11115.1

Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)

Predicted Functional Partners:

APX11114.1

0.912

APX11113.1

0.906

APX11112.1

0.560

APX10498.1

0.434

Your Current Organism:

Tateyamaria omphalii

NCBI taxonomy Id: 299262
Other names: IAM 15108, JCM 21569, KCTC 12333, T. omphalii, Tateyamaria omphalii Kurahashi and Yokota 2008 emend. Sass et al. 2010, strain MKT107

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APX10498.1	APX11115.1	BWR18_01360	BWR18_04980	Copper-translocating P-type ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.434
APX11112.1	APX11113.1	BWR18_04965	BWR18_04970	EamA family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Antibiotic biosynthesis monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
APX11112.1	APX11114.1	BWR18_04965	BWR18_04975	EamA family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	NIPSNAP family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
APX11112.1	APX11115.1	BWR18_04965	BWR18_04980	EamA family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.560
APX11113.1	APX11112.1	BWR18_04970	BWR18_04965	Antibiotic biosynthesis monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	EamA family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
APX11113.1	APX11114.1	BWR18_04970	BWR18_04975	Antibiotic biosynthesis monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NIPSNAP family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.960
APX11113.1	APX11115.1	BWR18_04970	BWR18_04980	Antibiotic biosynthesis monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.906
APX11114.1	APX11112.1	BWR18_04975	BWR18_04965	NIPSNAP family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	EamA family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
APX11114.1	APX11113.1	BWR18_04975	BWR18_04970	NIPSNAP family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Antibiotic biosynthesis monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.960
APX11114.1	APX11115.1	BWR18_04975	BWR18_04980	NIPSNAP family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
APX11115.1	APX10498.1	BWR18_04980	BWR18_01360	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Copper-translocating P-type ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.434
APX11115.1	APX11112.1	BWR18_04980	BWR18_04965	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	EamA family transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.560
APX11115.1	APX11113.1	BWR18_04980	BWR18_04970	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Antibiotic biosynthesis monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.906
APX11115.1	APX11114.1	BWR18_04980	BWR18_04975	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	NIPSNAP family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000105

Histidine biosynthetic process

9 of 10

2.49

7.99

1.38e-17

GO:0009058

Biosynthetic process

11 of 740

0.71

0.68

2.58e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000107

Imidazoleglycerol-phosphate synthase activity

2 of 2

2.54

0.99

0.0160

GO:0016763

Pentosyltransferase activity

3 of 18

1.76

0.91

0.0160

GO:0008483

Transaminase activity

3 of 24

1.64

0.88

0.0160

GO:0030170

Pyridoxal phosphate binding

3 of 42

1.39

0.69

0.0329

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1170

0.47

0.35

0.0073

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:942

Phenylalanine, tyrosine and tryptophan biosynthesis, and Histidine biosynthesis

10 of 26

2.12

6.65

1.33e-17

CL:977

Histidine biosynthesis

5 of 5

2.54

4.41

2.93e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00340

Histidine metabolism

10 of 28

2.09

6.65

3.86e-18

map01230

Biosynthesis of amino acids

10 of 150

1.36

2.4

9.01e-12

map00401

Novobiocin biosynthesis

2 of 3

2.36

1.49

0.0017

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

3 of 22

1.67

1.34

0.0013

map01110

Biosynthesis of secondary metabolites

10 of 535

0.81

0.82

1.40e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0368

Histidine biosynthesis

9 of 10

2.49

8.31

2.17e-18

KW-0963

Cytoplasm

7 of 228

1.03

5.51e-05

KW-0315

Glutamine amidotransferase

2 of 13

1.73

0.72

0.0392

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00977

Histidine biosynthesis protein

2 of 2

2.54

0.88

0.0249

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