Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
yaaHConserved hypothetical protein; Code: S; COG: COG1584; orf. (188 aa)    
Predicted Functional Partners:
ybaP
Putative ligase; Code: S; COG: COG3735.
      
 0.827
ynhA
Conserved hypothetical protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family.
      
 0.827
sanA
Vancomycin sensitivity; Code: S; COG: COG2949.
      
 0.827
yhbO
Conserved hypothetical protein; Code: R; COG: COG0693; orf.
      
 0.825
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
      
 0.737
lpxC
UDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
      
 0.588
SDY_0011
Putative oxidoreductase; Code: S; COG: COG4735.
  
  
 0.492
SDY_2877
Conserved hypothetical protein; Code: E; COG: COG1296; orf.
      
 0.480
yaaI
Conserved hypothetical protein; Belongs to the UPF0412 family.
  
  
 0.465
gapA
Glyceraldehyde-3-phosphate dehydrogenase A; Code: G; COG: COG0057; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
      
 0.439
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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