STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yadTConserved hypothetical protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. (266 aa)    
Predicted Functional Partners:
btuC
Vitamin B12 transport permease protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.
 
 
 0.998
btuD
ATP-binding component of vitamin B12 transport system; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
  
 
 0.946
shuU
Putative permease of iron compound ABC transport system; Code: P; COG: COG0609; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
 
 0.943
SDY_1241
Putative iron compound ABC transporter, permease protein; Code: P; COG: COG0609; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
 
 0.816
fecD
Citrate-dependent iron transporter membrane-bound protein; Code: P; COG: COG0609; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
 
 0.814
fhuC
ATP-binding component of hydroxymate-dependent iron transport; Code: PH; COG: COG1120.
 
 
 0.812
pfs
Conserved hypothetical protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP ph [...]
  
  
 0.811
fecC
Citrate-dependent iron(III) transport protein cytosolic; Code: P; COG: COG0609; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
 
 0.804
fhuD
Hydroxamate-dependent iron uptake, cytoplasmic membrane component; Code: P; COG: COG0614.
      
 0.785
fepD
Ferric enterobactin transport; Enterochelin transport; Code: P; COG: COG0609; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
 
 0.749
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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