STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phoBPositive response regulator for pho regulon; Sensor is PhoR (or CreC); Code: TK; COG: COG0745. (229 aa)    
Predicted Functional Partners:
arcB
Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642.
 
 0.976
barA
Sensor-regulator; Activates OmpR by phophorylation; Code: T; COG: COG0642.
 
 
 0.856
evgS
Putative sensor for regulator EvgA; Code: ET; COG: COG0834.
 
 
 0.850
phoQ
Sensor protein PhoQ; Code: T; COG: COG0642.
 
 
 0.834
basS
Sensor protein for basR; Code: T; COG: COG0642.
 
 
 0.819
envZ
Protein histidine kinase/phosphatase sensor for OmpR; Modulates expression of ompF and ompC; Code: T; COG: COG0642.
 
 0.783
cpxA
Histidine protein kinase; Probable sensor protein; acting on arcA; Code: T; COG: COG0642.
 
 0.773
rstB
Sensor histidine protein kinase; RstA regulator; Code: T; COG: COG0642.
 
 0.760
nuoC
NADH dehydrogenase I chain C, D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.
   
   0.757
yfhK
Putative 2-component sensor protein; Code: T; COG: COG0642.
 
 
 0.738
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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