STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lppMurein lipoprotein; Code: M; COG: COG4238. (78 aa)    
Predicted Functional Partners:
lolA
Periplasmic protein effects translocation of lipoproteins from inner membrane to outer; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
    
 
 0.838
tonB
TonB; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
    
   0.762
ompA
Outer membrane protein 3a; II*;G;d; Code: M; COG: COG2885; Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
  
 
 0.679
ycfU
Conserved hypothetical protein; Code: M; COG: COG4591; orf.
    
 
 0.578
pal
Peptidoglycan-associated lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
  
 
 0.573
ompC
Outer membrane protein 1b; Ib;c; Code: M; COG: COG3203; Belongs to the Gram-negative porin family.
   
  
 0.487
insB-65
IS1 ORF2.
       0.442
hemM
5-aminolevulinate synthesis enzyme, main pathway, possibly glutamyl-tRNA dehydrogenase; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
      
 0.412
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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