STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
focAProbable formate transporter; Formate channel 1; Code: P; COG: COG2116. (285 aa)    
Predicted Functional Partners:
pflB
Formate acetyltransferase 1; Code: C; COG: COG1882.
 
  
 0.783
srlR
Regulator for gut (srl) operon; Code: KG; COG: COG1349.
      
 0.781
ycaO
Conserved hypothetical protein; Code: S; COG: COG1944; orf.
     
 0.652
hycD
Membrane-spanning protein of hydrogenase 3; Part of FHL complex; Code: C; COG: COG0650.
 
   
 0.649
pflA
Pyruvate formate lyase activating enzyme 1; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.
      0.647
hycE
Large subunit of hydrogenase 3; Part of FHL complex; Code: C; COG: COG3261.
     
 0.644
hycI
HycI; Protease involved in processing C-terminal end of the large subunit of hydrogenase 3; Code: C; COG: COG0680.
 
   
 0.619
hycB
Probable small subunit of hydrogenase-3, iron-sulfur protein; Part of formate hydrogenlyase (FHL) complex; Code: C; COG: COG1142.
     
 0.601
moeA
Molybdopterin biosynthesis; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.
  
  
 0.550
hypE
HypE; Plays structural role in maturation of all 3 hydrogenases; Code: O; COG: COG0309.
      
 0.550
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.