STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypAPleiotrophic effects on 3 hydrogenase isozymes; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (116 aa)    
Predicted Functional Partners:
hypB
Guanine-nucleotide binding protein; Functions as nickel donor for large subunit of hydrogenase 3; Code: OK; COG: COG0378.
 
 
 0.997
hypD
Pleiotrophic effects on 3 hydrogenase isozymes; Code: O; COG: COG0409; Belongs to the HypD family.
  
 0.971
hypE
HypE; Plays structural role in maturation of all 3 hydrogenases; Code: O; COG: COG0309.
  
 0.951
hypC
Pleiotrophic effects on 3 hydrogenase isozymes; Code: O; COG: COG0298.
 
  
 0.911
yhhG
Conserved hypothetical protein; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.
     
 0.802
yohL
Conserved hypothetical protein; Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter (By similarity); Belongs to the FrmR/RcnR family.
      
 0.780
hypF
Transcriptional regulatory protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.749
hyaB
Hydrogenase-1 large subunit; Code: C; COG: COG0374.
 
 
 0.741
slyD
FKBP-type peptidyl-prolyl cis-trans isomerase; Rotamase; Code: O; COG: COG1047.
    
 
 0.701
hybC
Probable large subunit, hydrogenase-2; Code: C; COG: COG0374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.696
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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